Olfactory Capacity and Obesity: A Narrative Review of the Literature
Abstract The sense of smell plays a crucial role in food perception, influencing dietary choices and eating behavior. This narrative review explores the relationship between olfactory function and obesity, addressing the question: how does smell influence the perception, selection, and eating behavior of food? The review highlights that individuals with obesity may experience reduced olfactory […]
Olfactory Capacity and Obesity in Chilean Adolescents
Abstract Background: Childhood obesity is a global issue, influenced by energy-dense foods and powerful cues that affect brain areas regulating food intake. The olfactory system, linked to food preferences and consumption, is inversely related to body mass index. However, no studies have assessed the possible effect of eating behavior traits on the relationship between olfactory […]
Association between dopamine genes, adiposity, food addiction, and eating behavior in Chilean adult
Abstract Background: A frequent consumption of high sugar/fat foods can affect dopamine signaling in the brain and cause sustained stimulation of the reward system. It has been hypothesized that a hypodopaminergic trait results in an individual overeating in order to increase brain DA. Genetic variants in this route have been connected with addiction and eating […]
Validation of the baby eating behaviour questionnaire in a Chilean population
Eating behaviors traits are present from early infancy and are associated with a greater risk for obesity in childhood. The Baby Eating Behaviour Questionnaire (BEBQ) is a tool developed to measure eating behavior in infants. The aim of this study was to (i) translate, (ii) culturally adapt, and (iii) evaluate the psychometric properties of the […]
Genetic variation of the dopamine D2 receptor gene: association with the reinforcing value of food and eating in the absence of hunger in Chilean children
Obregón AM, Valladares Vega MA, Goldfield G, Llewellyn C. Nutr Hosp. 2020 Jul 13;34(3):524-533. doi: 10.20960/nh.02897. Background: food is a powerful reinforcer that motivates people to eat. The TaqI A1 polymorphism (rs1800497; T>C) downstream of the dopamine D2 receptor (DRD2) gene has been associated with diminished DRD2 receptor density, higher food reinforcement, and impaired eating […]
Association of the melanocortin 4 receptor gene rs17782313 polymorphism with rewarding value of food and eating behavior in Chilean children
Studies conducted in monozygotic and dizygotic twins have established a strong genetic component in eating behavior. Rare mutations and common variants of the melanocortin 4 receptor (MC4R) gene have been linked to obesity and eating behavior scores. However, few studies have assessed common variants in MC4R gene with the rewarding value of food in children. […]
Association of the dopamine D2 receptor rs1800497 polymorphism and eating behavior in Chilean children
Objectives: Studies have established a strong genetic component in eating behavior. The TaqI A1 polymorphism (rs1800497) has previously been associated with obesity and eating behavior. Additionally, this polymorphism has been associated with diminished dopamine D2 receptor (DRD2) density, higher body mass, and food reinforcement. The aim of this study was to evaluate the association between the […]
Effects of fat mass and obesity-associated (FTO) gene polymorphisms on binge eating in women with binge-eating disorder: The moderating influence of attachment style
Cameron JD, Tasca GA, Little J, Chyurlia L, Ritchie K, Yeh E, Doucette S, Obregon AM, Bulman DE, Doucet É, Goldfield GS. Nutrition. 2019 May;61:208-212. doi: 10.1016/j.nut.2018.11.006. Epub 2018 Nov Objectives: The genetics of binge-eating disorder (BED) is an emerging topic and one candidate pathway, namely the fat mass and obesity-associated (FTO) gene, may be […]
Association of the dopamine D2 receptor rs1800497 polymorphism with food addiction, food reinforcement, and eating behavior in Chilean adults
bregón AM, Oyarce K, García-Robles MA, Valladares M, Pettinelli P, Goldfield GS. Eat Weight Disord. 2022 Feb;27(1):215-224. doi: 10.1007/s40519-021-01136-1. Purpose: The regulation of food intake and body weight involves two interacting systems: (a) The homeostatic system (including biological regulators of hunger and satiety) and (b) the non-homeostatic system, (involving concepts of food reinforcement and food addiction). […]
No association of the dopamine D2 receptor genetic bilocus score on food addiction and food reinforcement in Chilean adults
Hidalgo Vira N, Oyarce K, Valladares Vega M, Goldfield GS, Guzmán-Gutiérrez E, Obregón AM. Front Behav Neurosci. 2023 Mar 31;17:1067384. doi: 10.3389/fnbeh.2023.1067384. eCollection 2023. Abstract Purpose: Different systems regulate food intake. In the reward system, dopamine (DA) is the main neurotransmitter, and a variety of genetic variants (rs1799732 and rs1800497) are associated with addiction. Addiction is […]